Crispr/Cas9 慢病毒

 

服务简介

       

Cas9DANBAIDECDSZHANGDA4kb,KELONGNANDUHEBAODUNANDUDOUXIANGDUIDA,JIANGCas9JIYINGAOXIAODAORUXIBAOSHIYINGYONGCas9/CRISPRXITONGJINXINGJIYINQIAOCHUDENANDIANZHIYI,JIDADIXIANZHIKEGONGXUANZEDEJIANGJIYINDAORUXIBAODEFANGFA。BINGQIEZAIYONGCRISPR/Cas9XITONGJINXINGJIYINQIAOCHUSHI,HAIXUYAOTONGSHIZHUANRUSHIBIEBADIANDEgRNA,SHAIXUANYANGXINGXIBAODEKANGXINGJIYINHUOYINGGUANGJIYIN,YONGTONGYUANZHONGZUFAJINXINGJIYINQIAOCHU,HAIXUYAODAORUTONGYUANZHONGZUMOBAN。RUCIDUODEJIYINGONGTONGBIAODA,HENNANDEDAOJIAOGAODEJIYINBIANJIXIAOLV,ZAOCHENGHOUXUDEYANGXINGKELONGSHAIXUANHEJIANCEGONGZUONANDUDA。

HANHENGSHENGWUDUCHUANGXINGYANFACHUMANBINGDUCas9BIAODATIXI,GAITIXICAIYONGMANBINGDUTIXIXIANZAIXIBAOZHONGWENDINGBIAODACas9DANBAI,GOUJIANWENDINGBIAODACas9DANBAIDEXIBAOXI,ZAIZAIGAIXIBAOXIDEJICHUSHANGDAORUgRNAHEJIYINQIAOCHUSHIYANZHONGYONGDAODEQITAYUANJIANYONGYUTEYIXINGJIYINQIAOCHU。

 

 

 亚博app官网优势

 

a、SHIYANFANGANSHEJIGENGLINGHUO。YOUYUBUBIBIAODADADANBAICas9,KEYIGENJUXIBAOTEXINGXUANZEHUAXUEZHUANRAN、XIANBINGDU、XIANXIANGGUANBINGDUDENGDUOZHONGFANGFADAORUHUOQIAOCHUXIANGGUANJIYIN;

 

b、TIGAOJIYINQIAOCHUXIAOLV。ZAIWENDINGBIAODACas9DANBAIDEXIBAOXISHANGJINXINGJIYINQIAOCHUBISHUNSHIZHUANRANCas9JINXINGJIYINQIAOCHUDEXIAOLVGENGGAO;

 

c、KEDUITONGYIXIBAOJINXINGDUOGEJIYINQIAOCHUSHIYAN。DUIYUXUYAOZAITONGYIGEXIBAOXIZHONGJINXINGDUOGEJIYINDEBIANJIHUOXUYAOZHANGQIYONGYIGEXIBAOMOXINGJINXINGDUOXIANGJIYINYANJIU,XIANGOUJIANYIGECas9DANBAIWENDINGBIAODADEXIBAOXIKEXIANZHUTIGAOHOUXUSHIYANDEXIAOLV,JIANGDISHIYANNANDU。

 

 

服务特点

 

a、SHIYONGYUZAITONGYIGEXIBAOXIZHONGXUYAOJINXINGDUOGEJIYINQIAOCHUDESHIYAN;

b、JIYINQIAOCHUXIAOLVBIZHIJIEZHILIZHUANRANGENGGAO;

c、TIGONGDUOZHONGBUTONGYINGGUANGHEKANGXINGBIAOJIDEMANBINGDUBIAODAZAITI,GENGYISHAIXUANDAOJIYINQIAOCHUCHENGGONGXIBAO;

d、JIESHOUcas9DANBAIWENDINGBIAODABUTONGXIBAOXIDINGZHI。

 

 

服务流程

 

 

 

A、cas9ZAITIGOUJIANJIMANBINGDUBAOZHUANG

JIANGcas9JIYINCDSQUKELONGZHIMANBINGDUZAITI,BINGJINXINGcas9MANBINGDUBAOZHUANG。

B、WENDINGZHUSHAIXUAN

JIANGcas9MANBINGDUGANRANTEDINGDEMUDEXIBAO,JINXINGcas9WENDINGBIAODADEXIBAOZHUSHAIXUAN。

 

 

CANKAOWENXIAN

   1、MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes;
     (2016年发表于JCI,作者:刘志红)
   2、TGF-β1 promotes osteosarcoma cell migration and invasion through the miR-143-versican pathway;
     (2014年发表于Cellular Physiology and Biochemistry,作者:Shaohua Li and Tao Cheng)
   3、miR-451a Inhibited Cell Proliferation and Enhanced Tamoxifen Sensitive in Breast Cancer via Macrophage Migration Inhibitory Factor;
     (2015年发表于BioMed Research International,作者:李红)
   4、Smad4 mediated BMP2 signal is essential for the regulation of GATA4 and Nkx2. 5 by affecting the histone H3 acetylation in H9c2 cells;
     (2014年发表于Biochemical and Biophysical Research Communications,作者:田杰)
   5、Effects and mechanism of downregulation of COX‑2 expression by RNA interference on proliferation and apoptosis of human breast cancer MCF‑7 cells;
     (2014年发表于Molecular Medicine Reports,作者:hui Han)
   6、MicroRNA-486-5p targeting PIM-1 suppresses cell proliferation in breast cancer cells;
     (2014年发表于Tumor Biology,作者:Zhenlin Yang)
   7、Cyc1 silencing sensitizes osteosarcoma cells to trail-induced apoptosis;
     (2014年发表于Cell Physiol Biochem,作者:Ke Zhou, and Biao Cheng)
   8、MicroRNA-23a is involved in tumor necrosis factor-α induced apoptosis in mesenchymal stem cells and myocardial infarction;
     (2014年发表于Experimental and Molecular Pathology,作者:Yu Zhuang)
   9、Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis;
     (2014年发表于Toxicology and Applied Pharmacology)
   10、CXCR4-targeted near-infrared imaging allows detection of orthotopic and metastatic human osteosarcoma in a mouse model;
     (2015年发表于Scientific Reports,作者:周勇)
   11、Role of high-mobility group box 1 in methamphetamine-induced activation and migration of astrocytes;
     (2015年发表于Journal of Neuroinflammation,作者:姚红红)
   12、The role of MCPIP1 in ischemia/reperfusion injury-induced HUVEC migration and apoptosis;
     (2015年发表于Cell Physiol Biochem,作者:Jie Chao)
   13、P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene;
     (2015年发表于Tumor Biology,作者:Jianru Xiao)
   14、CRCT1 regulated by microRNA-520 g inhibits proliferation and induces apoptosis in esophageal squamous cell cancer;
     (2015年发表于Tumor Biology,作者:Zhiming Chen)
   15、Overexpression of Hiwi Inhibits the Growth and Migration of Chronic Myeloid Leukemia Cells;
     (2015年发表于Cell Biochemistry and Biophysics,作者:Ziling Liu)
   16、RNF43 inhibits cancer cell proliferation and could be a potential prognostic factor for human gastric carcinoma;
     (2015年发表于Cell Physiol Biochem,作者:Lin Chen)
   17、ZC3H12D attenuated inflammation responses by reducing mRNA stability of proinflammatory genes;
     (2015年发表于Molecular Immunology,作者:Tao Jianga)
   18、MiR-146b-5p promotes metastasis and induces epithelial-mesenchymal transition in thyroid cancer by targeting ZNRF3;
     (2015年发表于Cell Physiol Biochem,作者:Xiaoping Zhang and Youben Fan)
   19、HSF1 Relieves Amyloid-β-Induced Cardiomyocytes Apoptosis;
     (2015年发表于Cell Biochemistry and Biophysics,作者:Beiru Zhang)
   20、Interaction between TNFR1 and TNFR2 dominates the clinicopathologic features of human hypopharyneal carcinoma;
     (2015年发表于Tumor Biology,作者:Qi Song)
   21、Periostin mediates TGF-β-Induced epithelial mesenchymal Transition in prostate cancer cells;
     (2015年发表于Cell Physiol Biochem,作者:Chuanyu Sun and Guowei Xia)
   22、CD49f acts as an inflammation sensor to regulate differentiation, adhesion, and migration of human mesenchymal stem cells;
     (2015年发表于STEM CELLS,作者:Ran Xiao)
   23、MCPIP1 regulates alveolar macrophage apoptosis and pulmonary fibroblast activation after in vitro exposure to silica;
     (2015年发表于Journal of Neuroinflammation ,作者:姚红红)
   24、MicroRNA-33b inhibits tumor cell growth and is associated with prognosis in colorectal cancer patients;
     (2015年发表于Clinical and Translational Oncology,作者:孙荣勋)
   25、MCPIP1 regulates alveolar macrophage apoptosis and pulmonary fibroblast activation after in vitro exposure to silica;
     (2015年发表于ToxSci Advance Access,作者:Jie Chao)
   26、miR‐152 induces human dental pulp stem cell senescence by inhibiting SIRT7 expression;
     (2015年发表于FEBS letters,作者:Jingping Liang)
   27、Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, and induces apoptosis;
     (2015年发表于International Journal of Molecular Medicine,作者:Hui Li)
   28、miR-486-5p inhibits cell growth of papillary thyroid carcinoma by targeting fibrillin-1;
     (2015年发表于Biomedicine & Pharmacotherapy,作者:Jianqing Tian )
   29、Over-expression of miR-451a can enhance the sensitivity of breast cancer cells to tamoxifen by regulating 14-3-3ζ, estrogen receptor α, and autophagy;
     (2016年发表于Life Sciences,作者:Li-Mimg Zhou、Yuan-Yuan Zhang )
   30、MicroRNA-30a promotes chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression;
     (2016年发表于Life Sciences,作者:Ye Tian)
   31、MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6;
     (2016年发表于Biochemical and Biophysical Research Communications,作者:Xinguang Liu )
   32、Silencing of Paternally Expressed Gene 10 Inhibits Trophoblast Proliferation and Invasion;
     (2015年发表于PloS one,作者:Tao Meng)
   33、Repair of critical-sized bone defects with anti-miR-31-expressing bone marrow stromal stem cells and poly (glycerol sebacate) scaffolds;
     (2014年发表于European cells & materials,作者:Deng Yuan)
   34、MicroRNA-22 induces endothelial progenitor cell senescence by targeting AKT3;
     (2014年发表于Cell Physiol Biochem ,作者:Xu Z)
   35、A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis;
     (2015年发表于Tumor Biology,作者:Changjun Yin)
   36、p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis;
     (2015年发表于Sci Rep,作者:Jie Chao)
   37、Endocytosis mediated by Caveolin-1 inhibits activity of matrix metalloproteinase-2 in human renal proximal tubular cells under hypoxia;
     (2016年发表于Int J Clin Exp Pathol,作者: Jun Dou )
   38、MTSS1 suppresses cell migration and invasion by targeting CTTN in glioblastoma;
     (2015年发表于Journal of Neuro-Oncology,作者:Qigui Qi)
   39、PFDN1, an indicator for colorectal cancer prognosis, enhances tumor cell proliferation and motility through cytoskeletal reorganization;
     (2015年发表于Medical Oncology,作者:Minhua Zheng )
   40、Human Dental Pulp Stem Cells via the NF-κB Pathway;
     (2015年发表于Cell Physiol Biochem,作者:Jingping Liang )
   41、Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer;
     (2016年发表于Oncol Rep,作者:Peng Z)
   42、58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability;
     (2016年发表于Sci Rep,作者:Xiaoling Wang)
   43、Study of Arsenic Sulfide in Solid Tumor Cells Reveals Regulation of Nuclear Factors of Activated T-cells by PML and p53;
     (发表于Sci Rep,作者:Chen S1)
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