服务简介

 

ZHONGLIU（Tumor） SHIJITIZAIGEZHONGZHIAIYINSUZUOYONGXIA，JUBUZUZHIDEMOUYIGEXIBAOZAIJIYINSHUIPINGSHANGSHIQUDUIQISHENGZHANGDEZHENGCHANGDIAOKONG，DAOZHIQIKELONGXINGYICHANGZENGSHENGERXINGCHENGDEYICHANGBINGBIAN。XUEJIEYIBANJIANGZHONGLIUFENWEILIANGXINGHEEXINGLIANGDALEI。

CHANGJIANDEZHONGLIUZHILIAOFANGFAYOUZHONGYAOZHILIAO，HUALIAOYUMIANYIZHILIAOLIANHE，KANGXUEGUANSHENGCHENGZHILIAO，CICHANGZHILIAOHEYINLELIAOFADENG。HANHENGSHENGWUGENJUZHONGLIUTEXINGHEXIANDAIXIANJINSHENGWUXUEJISHUTIGONGXIANJINDEZHONGLIUYANJIUFANGFA，KEWEIZHONGLIUZHILIAOTIGONGHENDABANGZHU。

 

 

服务内容

 

1、YANGBENJI:ZUZHI、XUEYE、XIBAOYANGBENHUOQU；

 

2、BADIANYUXIANGGUANXINHAOTONGLUSHAICHAJIYANZHENG：

 

1）BADIANSHAICHA：GEZHONGXINPIAN，ERDAICEXUDENG；

2）XINHAOTONGLU：XIANGGUANFENXI，RUlncRNA、microRNAJIANCEDENG；

3）YANZHENG：TIWAIYANZHENGHETINEIYANZHENG；

 

3、BEIXUANBADIANDEGONGNENGZUXUEYANZHENGJIXIAYOUTONGLUSHAIXUAN

 

1）XIBAOSHUIPING ZHENDUITEDINGDEBADIAN，ZAITONGGUOgain of function/loss of function，ZAIXIBAOSHUIPINGMINGQUEQIBADIANDEGONGNENGHEYUZHONGLIUDEGUANXI;

2）动物水平 通过KI/KO动物模型进行相关研究；

 

4、XIBAOSHUIPINGBADIANSHANGXIAYOUDEXINHAOTONGLUJIZUOYONGJIZHIYANJIU

 

   1) 过高通量筛查（芯片，蛋白组学、pull-down、酵母双杂、文献等）进一步明确靶点的上下游启动子、miRNA、LncRNA和自噬等相关基因；

   2) TONGGUOgain of function/loss of function，XIBAOSHUIPINGYANZHENGBADIANYUXIANGGUANFENZITONGLUDEMINGQUESHANGXIAYOUGUANXI；

 

5、DONGWUSHUIPINGBADIANSHANGXIAYOUDEXINHAOTONGLUJIZUOYONGJIZHIYANJIU

 

1）TONGGUOTEDINGXINHAOTONGLUJIDONGJI/YIZHIJI，ZHENGMINGBADIANYUXIANGGUANFENZITONGLUDEMINGQUESHANGXIAYOUGUANXI；

2）进一步通过基因gain of function/loss of function证明靶点与相关分子通路关系，明确上下游关系（Tg/KO mouse）；

 

6、BADIANYUSHANGXIAYOUBAFENZIDEJINGXIDIAOKONGGUANXIJIANCE

 

1）DANBAIJIANXIANGHUZUOYONGGUANXI：TONGGUOCo-IP，pull-down，FRET；

2）SHANGXIAYOUZHUANLUDIAOJIE：TONGGUOpromoter-luciferaseXITONG，EMSADENG； 

3）针对更精细的分子作用区域研究：通过突变、截断体等研究相互作用结构域,比如蛋白间相互作用的精细结构域寻找；

 

 

7、药物筛选模型建立与药物筛选

 

 MINGQUEZHONGLIUBADIANJIQIXIANGGUANTONGLUDEFENZIJIZHI，GENJUBADIANJIQIXIAYOUXINHAOTONGLUDETEXING，JIANLITEYIXINGDEZHONGLIUYAOWUSHAIXUANMOXING，TONGGUOGAOTONGLIANGSHAIXUANPINGTAI（HTS），CONGHUAHEWUKUZHONGJINXINGTEYIXINGYAOWUDESHAIXUAN。

 

 

服务流程

 

 

 

服务优势

 

a、YILIUDEZHONGLIUYANJIUJISHUTUANDUI；

b、KUAISUDEFANGANQUEDING；

c、QUANFANGBIANFUWUGENZONG；

d、ZHUANYEDEJISHUZIXUN。